Article
Overcoming Resistance to FLT3 Inhibitors in the Treatment of FLT3-Mutated AML.
International journal of molecular sciences - 24 Feb 2020
Lam Stephen S Y, Leung Anskar Y H
Abstract excerpt
Acute myeloid leukaemia (AML) carrying internal tandem duplication (ITD) of Fms-Like Tyrosine kinase 3 (FLT3) gene is associated with high risk of relapse and poor clinical outcome upon treatment with conventional chemotherapy. FLT3 inhibitors have been approved for the treatment of this AML subtype but leukaemia relapse remains to be a major cause of treatment failure. Mechanisms of drug resistance have been...
Topics
- Aniline Compounds
- Antineoplastic Combined Chemotherapy Protocols
- Drug Resistance, Neoplasm
- Drug Therapy, Combination
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Protein Kinase Inhibitors
- Pyrazines
- Staurosporine
- fms-Like Tyrosine Kinase 3