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Article

RNA-Seq Accurately Identifies Cancer Biomarker Signatures to Distinguish Tissue of Origin

1 Nov 2014

Abstract excerpt

Metastatic cancer of unknown primary (CUP) accounts for up to 5% of all new cancer cases, with a 5-year survival rate of only 10%. Accurate identification of tissue of origin would allow for directed, personalized therapies to improve clinical outcomes. Our objective was to use transcriptome sequencing (RNA-Seq) to identify lineage-specific biomarker signatures for the cancer types that most commonly metastasize...

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PMID: 25425966
DOI: 10.1016/j.neo.2014.09.007

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