Article
A rapid, multiplex digital PCR assay to detect gene variants and fusions in non-small cell lung cancer.
Molecular oncology - 1 Nov 2023
Leatham Bryan, McNall Katie, Subramanian Hari K K, Jacky Lucien, Alvarado John, Yurk Dominic, Wang Mimi, Green Donald C, Tsongalis Gregory J, Rajagopal Aditya, Schwartz Jerrod J
Abstract excerpt
Digital PCR (dPCR) is emerging as an ideal platform for the detection and tracking of genomic variants in cancer due to its high sensitivity and simple workflow. The growing number of clinically actionable cancer biomarkers creates a need for fast, accessible methods that allow for dense information content and high accuracy. Here, we describe a proof-of-concept amplitude modulation-based multiplex dPCR assay...
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