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Article

The Role of Oocyte‐Secreted Factors GDF9 and BMP15 in Follicular Development and Oogenesis

30 Dec 2010

Abstract excerpt

Ovarian physiology is controlled by endocrine and paracrine signals, and the transforming growth factor β (TGFβ) superfamily has a pivotal role in this control. The Bone morphogenetic protein 15 (BMP15) and Growth differentiation factor 9 (GDF9) genes are relevant members of the TGFβ superfamily that encode proteins secreted by the oocytes into the ovarian follicles. Through a paracrine signalling pathway, these...

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PMID: 21198974
DOI: 10.1111/j.1439-0531.2010.01739.x

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