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Inhibition of Premature Oocyte Maturation: A Role for Bone Morphogenetic Protein 15 in Zebrafish Ovarian Follicles

27 Jul 2007

Abstract excerpt

Bone morphogenetic protein-15 (BMP-15) is a member of the TGF-beta superfamily known to regulate ovarian functions in mammals. Recently, we cloned zebrafish BMP-15 (zfBMP-15) cDNA and demonstrated that it may play a role in oocyte maturation. In this study, we further investigated the role of BMP-15 in zebrafish follicular development and oocyte maturation using an antiserum developed for zfBMP-15 and by...

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PMID: 17656459
DOI: 10.1210/en.2007-0674

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