Mismatch repair deficiency reshapes glioblastoma through immune suppression rather than hypermutation.

Abstract excerpt

Mismatch repair (MMR) deficiency is classically associated with microsatellite instability, a high tumor mutational burden (TMB), and sensitivity to immune checkpoint blockade in cancer. In this issue of the JCI, Puigdelloses Vallcorba et al. reported that this paradigm does not hold true in glioblastoma (GBM). Using genetically engineered mouse models, the authors demonstrated that loss of core MMR genes was...

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• Brain Neoplasms
• Colorectal Neoplasms
• DNA Mismatch Repair
• Glioblastoma
• Mice