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Article

Identification of molecular subtypes based on liquid-liquid phase separation and cross-talk with immunological phenotype in bladder cancer.

Frontiers in immunology - 1 Jan 2022

Sun Le, Liu Xiao-Ping, Yan Xin, Wu Shaojie, Tang Xiaoyu, Chen Chen, Li Gang, Hu Hankun, Wang Du, Li Sheng

Abstract excerpt

Background: Mounting evidence has demonstrated that an imbalance in liquid-liquid phase separation (LLPS) can induce alteration in the spatiotemporal coordination of biomolecular condensates, which plays a role in carcinogenesis and cachexia. However, the role of LLPS in the occurrence and progression of bladder cancer (BLCA) remains to be elucidated. Identifying the role of LLPS in carcinogenesis may aid in...

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Identifiers

PMID: 36518754
DOI: 10.3389/fimmu.2022.1059568
PMCID: PMC9742536

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