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Article

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

24 Aug 2023

Abstract excerpt

Bladder cancer (BLCA) is more common in men but more aggressive in women. Sex-based differences in cancer biology are commonly studied using a murine model with BLCA generated by N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN). While tumors in the BBN model have been profiled, these profiles provide limited information on the tumor microenvironment. Here, we applied single-cell RNA sequencing to characterize...

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PMID: 37701814
DOI: 10.1016/j.isci.2023.107703

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