Article
Detection and localization of surgically resectable cancers with a multi-analyte blood test.
Science (New York, N.Y.) - 23 Feb 2018
Cohen Joshua D, Li Lu, Wang Yuxuan, Thoburn Christopher, Afsari Bahman, Danilova Ludmila, Douville Christopher, Javed Ammar A, Wong Fay, Mattox Austin, Hruban Ralph H, Wolfgang Christopher L, Goggins Michael G, Dal Molin Marco, Wang Tian-Li, Roden Richard, Klein Alison P, Ptak Janine, Dobbyn Lisa, Schaefer Joy, Silliman Natalie, Popoli Maria, Vogelstein Joshua T, Browne James D, Schoen Robert E, Brand Randall E, Tie Jeanne, Gibbs Peter, Wong Hui-Li, Mansfield Aaron S, Jen Jin, Hanash Samir M, Falconi Massimo, Allen Peter J, Zhou Shibin, Bettegowda Chetan, Diaz Luis A, Tomasetti Cristian, Kinzler Kenneth W, Vogelstein Bert, Lennon Anne Marie, Papadopoulos Nickolas
Abstract excerpt
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests...
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