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Article

Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway.

Molecular medicine (Cambridge, Mass.) - 20 Dec 2024

Shen Xiao-Hua, Xiong Shu-Ping, Wang Sheng-Peng, Lu Shan, Wan Yi-Ye, Zhang Hui-Qing

Abstract excerpt

BACKGROUND: Recently, the incidence of pancreatic cancer (PC) has gradually increased. Research has shown that UTX mutants are critical in tumors. However, the underlying mechanisms remain incompletely understood. This study aimed to explore how UTX mutation would affect its related function in PC. METHOD: Exome sequencing was used to analyze PC samples. MTT, transwell, and colony formation assays were performed...

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Source

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Identifiers

PMID: 39707168
DOI: 10.1186/s10020-024-01023-2
PMCID: PMC11660670

Genes

PC
G0S2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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