Article
Refined criteria for p53 expression in ovarian mucinous tumours are highly concordant with TP53 mutation status, but p53 expression/TP53 status lack prognostic significance.
Pathology - 1 Oct 2023
Dundr Pavel, Hájková Nikola, Kendall Bártů Michaela, Cibula David, Drozenová Jana, Fabian Pavel, Fadare Oluwole, Frühauf Filip, Hausnerová Jitka, Hojný Jan, Laco Jan, Lax Sigurd F, Matěj Radoslav, Méhes Gábor, Michálková Romana, Němejcová Kristýna, Singh Naveena, Stolnicu Simona, Švajdler Marián, Zima Tomáš, McCluggage W Glenn, Stružinská Ivana
Abstract excerpt
In gynecological neoplasms, immunohistochemical (IHC) expression of p53 is generally an accurate predictor of TP53 mutation status if correctly interpreted by the pathologist. However, the literature concerning cut-offs, frequency and prognostic significance of p53 staining in ovarian mucinous tumours is limited and heterogeneous. We performed an analysis of 123 primary ovarian mucinous tumours including mucinous...
Topics
- Female
- Humans
- Tumor Suppressor Protein p53
- Immunohistochemistry
- Ovarian Neoplasms
- Prognosis
- Mutation
- Adenocarcinoma, Mucinous