Article
Fluorescence detection of apolipoprotein E gene polymorphisms based on oligonucleotide ligation and magnetic separation.
Analytical methods : advancing methods and applications - 21 Sept 2023
Wen Wan-Chen, Lin Yi-Hui, Duh Tsai-Hui, Chen Chun-Hsien, Feng Chia-Hsien, Chen Yen-Ling
Abstract excerpt
Alzheimer's disease is a progressive neurodegenerative condition that causes brain cell death and is the leading cause of dementia. Most patients with Alzheimer's disease are diagnosed with late-onset Alzheimer's disease (LOAD), with apolipoprotein E (APOE) genotypes being highly associated with the frequency of LOAD risk. A fluorescence detection system coupled with oligonucleotide ligation and magnetic...
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