Article
Evidence of a Sjögren's disease-like phenotype following COVID-19 in mice and humans.
JCI insight - 22 Dec 2023
Shen Yiran, Voigt Alexandria, Goranova Laura, Abed Mehdi, Kleiner David E, Maldonado Jose O, Beach Margaret, Pelayo Eileen, Chiorini John A, Craft William F, Ostrov David A, Ramiya Vijay, Sukumaran Sukesh, Brown Ashley N, Hanrahan Kaley C, Tuanyok Apichai, Warner Blake M, Nguyen Cuong Q
Abstract excerpt
Sjögren's Disease (SjD) is a systemic autoimmune disease characterized by lymphocytic inflammation of the lacrimal and salivary glands (SG), dry eyes and mouth, and systemic symptoms. SARS-CoV-2 may trigger the development or progression of autoimmune diseases. To test this, we used a mouse model of SARS-CoV-2 infection and convalescent patients' blood and SG in order to understand the development of SjD-like...
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