Article

Reclassification of Variants of Uncertain Significance in BRCA1, BRCA2, and PALB2: Implications for Clinical Decision-Making in Breast Cancer

2026-06-28

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Germline pathogenic variants in high-penetrance breast cancer susceptibility genes, including BRCA1, BRCA2, and PALB2, play a pivotal role in risk assessment, therapeutic decision-making, and preventive strategies. The reclassification of VUS through standardized frameworks and emerging evidence is essential to enhance their clinical utility. <bold>Materials...

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Literature Corpus work: df76bf28-17c4-5882-9cae-04e4c197d2b5
DOI: 10.21203/rs.3.rs-9924373/v1

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