Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

Abstract excerpt

Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families. Here we propose an original approach based on 1) the detection of conserved sequence modules using partial local multiple alignment, 2) the phylogenetic inference of...

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