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Article

Neurocranial growth in the OIM mouse model of osteogenesis imperfecta.

Anatomical record (Hoboken, N.J. : 2007) - 1 Mar 2024

Husain Tooba S, Moore Jacob C, Huston Lila A, Miller Courtney A, Steele Ashley T, Gonzales Lauren A, Handler Emma K, Organ Jason M, Menegaz Rachel A

Abstract excerpt

Osteogenesis imperfecta (OI) is a disorder of type I collagen characterized by abnormal bone formation. The OI craniofacial phenotype includes midfacial underdevelopment, as well as neurocranial changes (e.g., macrocephaly and platybasia) that may also affect underlying nervous tissues. This study aims to better understand how OI affects the integrated development of the neurocranium and the brain. Juvenile and...

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PMID: 37638403
DOI: 10.1002/ar.25307

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