Article
LncRNA MALAT1 Promotes STAT3-Mediated Endothelial Inflammation by Counteracting the Function of miR-590.
Cytogenetic and genome research - 1 Jan 2020
Zhou Qing, Run Qi, Li Chen-Yu, Xiong Xiang-Yu, Wu Xiao-Lin
Abstract excerpt
The excessive production of inflammatory mediators by vascular endothelial cells (ECs) greatly contributes to the development of atherosclerosis. In this study, we explored the potential effect of lncRNA MALAT1 on endothelial inflammation. First, the EC inflammation model was constructed by treating human umbilical vein ECs (HUVECs) and human coronary artery ECs (HCAECs) with oxidized low-density lipoprotein...
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