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Article

The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension

24 Aug 2023

Abstract excerpt

Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the formation of autophagosomes. WIPI1, instead, assists WIPI2 in efficiently recruiting the ATG16L1 complex at the nascent autophagosome, which in turn promotes lipidation of LC3/GABARAP and autophagosome maturation. However, the specific role of WIPI1 and its regulation...

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PMID: 37620393
DOI: 10.1038/s42003-023-05236-9

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