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Article

Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations.

ACS chemical neuroscience - 6 Sept 2023

Solovyev Nikolay, Lucio Marianna, Mandrioli Jessica, Forcisi Sara, Kanawati Basem, Uhl Jenny, Vinceti Marco, Schmitt-Kopplin Philippe, Michalke Bernhard

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a lethal progressive neurodegenerative disease, characterized by a loss of function of upper and lower motor neurons. This study aimed to explore probable pathological alterations occurring in individuals with ALS compared to neurologically healthy controls through the analysis of cerebrospinal fluid (CSF), a medium, which directly interacts with brain parenchyma. A total of...

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Identifiers

PMID: 37608584
DOI: 10.1021/acschemneuro.3c00128
PMCID: PMC10485893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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