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Article

Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay.

PloS one - 1 Jan 2023

Slott Sofie, Krüger-Jensen Cecilie Schiøth, Ferreira da Silva Izabela, Pedersen Nadia Bom, Astakhova Kira

Abstract excerpt

We describe a quantitative detection method for mutated microRNA in human plasma samples. Specific oligonucleotides designed from a Peyrard-Bishop model allowed accurate prediction of target:probe recognition affinity and specificity. Our amplification-free tandem bead-based hybridization assay had limit of detection of 2.2 pM. Thereby, the assay allowed identification of single-nucleotide polymorphism mismatch...

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Identifiers

PMID: 37607185
DOI: 10.1371/journal.pone.0289556
PMCID: PMC10443835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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