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Role of efflux pumps, their inhibitors, and regulators in colistin resistance

4 Aug 2023

Abstract excerpt

Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However, the current understanding cannot fully explain the resistance mechanism in mcr -negative colistin-resistant strains. Significantly, the contribution of efflux...

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PMID: 37601369
DOI: 10.3389/fmicb.2023.1207441

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