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NOX family NADPH oxidases in mammals: Evolutionary conservation and isoform-defining sequences

12 Aug 2023

Abstract excerpt

NADPH oxidases are superoxide-producing enzymes that play a role in host defense, biosynthetic pathways, as well as cellular signaling. Humans have 7 NOX isoforms (NOX1-5, DUOX1,2), while mice and rats lack NOX5 and therefore have only 6 NOX isoforms. Whether all human NOX isoforms or their subunits (CYBA, NCF1, 2, 4, NOXO1, NOXA1, DUOXA1, 2) are present and conserved in other mammalian species is unknown. In...

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PMID: 37595375
DOI: 10.1016/j.redox.2023.102851

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