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Article

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.

Gastroenterology - 1 Apr 2016

Hirsova Petra, Ibrahim Samar H, Krishnan Anuradha, Verma Vikas K, Bronk Steven F, Werneburg Nathan W, Charlton Michael R, Shah Vijay H, Malhi Harmeet, Gores Gregory J

Abstract excerpt

BACKGROUND & AIMS: Hepatocyte cellular dysfunction and death induced by lipids and macrophage-associated inflammation are characteristics of nonalcoholic steatohepatitis (NASH). The fatty acid palmitate can activate death receptor 5 (DR5) on hepatocytes, leading to their death, but little is known about how this process contributes to macrophage-associated inflammation. We investigated whether lipid-induced DR5...

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Identifiers

PMID: 26764184
DOI: 10.1053/j.gastro.2015.12.037
PMCID: PMC4808464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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