Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell priming transcriptomic markers: implications of immunome heterogeneity for precision immunotherapy

8 Aug 2023

Abstract excerpt

Immune checkpoint blockade is effective for only a subset of cancers. Targeting T-cell priming markers (TPMs) may enhance activity, but proper application of these agents in the clinic is challenging due to immune complexity and heterogeneity. We interrogated transcriptomics of 15 TPMs (CD137, CD27, CD28, CD80, CD86, CD40, CD40LG, GITR, ICOS, ICOSLG, OX40, OX40LG, GZMB, IFNG, and TBX21) in a pan-cancer cohort (N...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37553332
DOI: 10.1038/s41525-023-00359-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-cell priming transcriptomic markers: implications of immunome heterogeneity for precision immunotherapyPMID 37553332Read ↗

Immune Subtyping for Pancreatic Cancer with Implication in Clinical Outcomes and Improving ImmunotherapySemantic proximity Read ↗

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade.Semantic proximity Read ↗

A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment.Semantic proximity Read ↗

Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacySemantic proximity Read ↗

The Immune Landscape of CancerSemantic proximity Read ↗

A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity Read ↗

Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development.Semantic proximity Read ↗

A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockadeSemantic proximity Read ↗

Immune Checkpoints are Predominantly Co-Expressed by Clonally Expanded CD4+FoxP3+ Intratumoral T-cells in Primary Human CancersSemantic proximity Read ↗

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapySemantic proximity Read ↗

Classification of tumor microenvironment immune types based on immune response-associated gene expressionSemantic proximity Read ↗

Pan-cancer analysis of tumor mutation burden sensitive tumors reveals tumor-specific subtypes and hub genes related to immune infiltration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.