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Article

Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients.

Cancer immunology, immunotherapy : CII - 1 Dec 2021

Rodin William, Sundström Patrik, Ahlmanner Filip, Szeponik Louis, Zajt Kamil Kajetan, Wettergren Yvonne, Bexe Lindskog Elinor, Quiding Järbrink Marianne

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are unconventional T cells recognizing microbial metabolites, presented by the invariant MR1 protein. Upon activation, MAIT cells rapidly secrete cytokines and exert cytotoxic functions, and may thus be highly relevant also in tumor immunity. MAIT cells accumulate in colon tumors, but in contrast to other cytotoxic T cell subsets, their presence in tumors has been...

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Identifiers

PMID: 33885944
DOI: 10.1007/s00262-021-02939-y
PMCID: PMC8571139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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