Article
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
The Journal of experimental medicine - 7 Dec 2020
Jouan Youenn, Guillon Antoine, Gonzalez Loïc, Perez Yonatan, Boisseau Chloé, Ehrmann Stephan, Ferreira Marion, Daix Thomas, Jeannet Robin, François Bruno, Dequin Pierre-François, Si-Tahar Mustapha, Baranek Thomas, Paget Christophe
Abstract excerpt
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class...
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