Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

11 Jul 2023

Abstract excerpt

Iroquois transcription factor gene IRX3 is highly expressed in 20–30% of acute myeloid leukemia (AML) and contributes to the pathognomonic differentiation block. Intron 8 FTO sequences ∼220kB downstream of IRX3 exhibit histone acetylation, DNA methylation, and contacts with the IRX3 promoter, which correlate with IRX3 expression. Deletion of these intronic elements confirms a role in positively regulating IRX3 ....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37539037
DOI: 10.1016/j.isci.2023.107319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTOPMID 37539037Read ↗

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute LeukemiaSemantic proximity Read ↗

Focal Deletions of a Promoter Tether Activate the <i>IRX3</i> Oncogene in T Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.Semantic proximity Read ↗

The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemiaSemantic proximity Read ↗

A role for the transcription intermediary factor 2 in zebrafish myelopoiesis.Semantic proximity Read ↗

Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemiaSemantic proximity Read ↗

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangementsSemantic proximity Read ↗

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AMLSemantic proximity Read ↗

Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells.Semantic proximity Read ↗

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesisSemantic proximity Read ↗

Transforming growth‐interacting factor (<i>TGIF</i>) regulates proliferation and differentiation of human myeloid leukemia cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.