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Article

A putative role for ALDH inhibitors and chemoprevention of BRCA-mutation-driven tumors.

Gynecologic oncology - 1 Sept 2023

McGonigal Stacy, Wu Rong, Grimley Ed, Turk Ekrem G, Zhai Yali, Cho Kathleen R, Buckanovich Ronald J

Abstract excerpt

Aldehyde dehydrogenase (ALDH) enzymatic activity is a marker of cancer-initiating cells (CIC) in many tumor types. Our group and others have found that ALDH1A family inhibitors (ALDHi) can preferentially induce death of ovarian CIC in established ovarian cancer. We sought to determine if ALDHi, by targeting CIC at the time of tumor initiation, could function as a chemopreventive for ovarian cancer. As BRCA1/2...

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Identifiers

PMID: 37535994
DOI: 10.1016/j.ygyno.2023.07.015
PMCID: PMC10653209

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