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Article

Development of a Fluorescent Probe for M2 Macrophages via Gating-Oriented Live-Cell Distinction.

Journal of the American Chemical Society - 8 Feb 2023

Cho Heewon, Kwon Haw-Young, Lee Sun Hyeok, Lee Hong-Guen, Kang Nam-Young, Chang Young-Tae

Abstract excerpt

Macrophages are the most plastic immune cells by changing their characters in response to environmental stimuli. Broadly, macrophages are categorized into two different subsets based on M1/M2 paradigm, which exhibit completely contrary phenotypes. Whereas M1 macrophages are aggressive to offend invaders such as bacteria and tumors, M2 are anti-inflammatory cells and seemingly help tumor immunity. Tumor-associated...

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PMID: 36705574
DOI: 10.1021/jacs.2c11393

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