Article
Expression of interleukin-36 receptor antagonist in a patient with generalized pustular psoriasis harboring the p.Pro82Leu variant in the IL36RN gene.
The Journal of dermatology - 1 Dec 2023
Mizukawa Itsumi, Kamata Masahiro, Shimizu Teruo, Ito Makoto, Watanabe Ayu, Uchida Hideaki, Egawa Shota, Nagata Mayumi, Fukaya Saki, Hayashi Kotaro, Fukuyasu Atsuko, Tanaka Takamitsu, Ishikawa Takeko, Sugiura Kazumitsu, Tada Yayoi
Abstract excerpt
It has recently been revealed that mutation of the IL36RN gene contributes to the development of generalized pustular psoriasis (GPP). The IL36RN gene encodes interleukin (IL)-36 receptor antagonist (IL-36Ra), which has antagonistic roles against IL-36α, -36β, and -36γ. Previously, sanger sequencing performed in 62 Chinese GPP patients to identify IL36RN mutations revealed a new variant, c.245C>T (p.Pro82Leu), in...
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