Article
Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis.
Human mutation - 1 Jan 2013
Farooq Muhammad, Nakai Hiroyuki, Fujimoto Atsushi, Fujikawa Hiroki, Matsuyama Asako, Kariya Naoyuki, Aizawa Atsuko, Fujiwara Hiroshi, Ito Masaaki, Shimomura Yutaka
Abstract excerpt
Generalized pustular psoriasis (GPP) is a rare, potentially life threatening, and aggressive form of psoriasis, which is characterized by sudden onset with repeated episodic skin inflammation leading to pustule formation. Familial GPP is known to be caused by recessively inherited mutations in the IL36RN gene, which encodes interleukin 36 receptor antagonist (IL-36Ra). In this article, we performed mutation...
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