Article
Mutation analysis of the IL36RN gene in Chinese patients with generalized pustular psoriasis with/without psoriasis vulgaris.
Journal of dermatological science - 1 Nov 2014
Li Xiuyan, Chen Mingfei, Fu Xi'an, Zhang Qilin, Wang Zhenzhen, Yu Gongqi, Yu Yongxiang, Qin Peipei, Wu Weizhi, Pan Futang, Liu Hong, Zhang Furen
Abstract excerpt
BACKGROUND: Generalized pustular psoriasis (GPP) is a rare type of psoriasis with potentially life-threatening implications. Mutations in IL36RN gene have been suggested to be causative or predisposing factors for GPP. OBJECTIVE: To evaluate the genetic heterogeneity of GPP, PV and GPP alone, GPP with PV. METHODS: We performed a sanger sequencing identify IL36RN mutations in 62 Chinese Han patients with sporadic...
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