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Article

The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist.

The Journal of investigative dermatology - 1 Nov 2013

Sugiura Kazumitsu, Takemoto Akemi, Yamaguchi Michiya, Takahashi Hidetoshi, Shoda Yukiko, Mitsuma Teruyuki, Tsuda Kenshiro, Nishida Emi, Togawa Yaei, Nakajima Kimiko, Sakakibara Akihiro, Kawachi Shigeo, Shimizu Makoto, Ito Yasutomo, Takeichi Takuya, Kono Michihiro, Ogawa Yasushi, Muro Yoshinao, Ishida-Yamamoto Akemi, Sano Shigetoshi, Matsue Hiroyuki, Morita Akimichi, Mizutani Hitoshi, Iizuka Hajime, Muto Masahiko, Akiyama Masashi

Abstract excerpt

Generalized pustular psoriasis (GPP) is a rare inflammatory skin disease that can be life-threatening. Recently, it has been reported that familial GPP is caused by homozygous or compound heterozygous mutations of IL36RN. However, the majority of GPP cases are sporadic and it is controversial whe...

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PMID: 23698098
DOI: 10.1038/jid.2013.230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23698098-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist.PMID 23698098Read ↗

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IL36RN gene analysis of two Japanese patients with generalized pustular psoriasis.Semantic proximity Read ↗

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