Article

Single-cell foundation models identify shared and divergent transcriptomic signatures of aging across invertebrates and mammals

2026-07-27

Abstract excerpt

Cross-species aging clocks have so far stayed within mammals. We asked whether a single model can predict age from single cells of fly, worm, mouse, and human, species separated by roughly 800 million years of evolution. We fine-tuned scGPT and Geneformer on 1.3 million such cells, using one parameter set per architecture. Both models classified cells as young, middle, or old, reaching 78.6% and 80.5% accuracy. SH...

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Literature Corpus work: 55aba163-9f16-5768-9bd8-8bc5f4f29b0a
DOI: 10.64898/2026.07.24.740647

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