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Article

Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis.

Clinical science (London, England : 1979) - 14 Aug 2023

Tang Qiaoli, Shi Wanting, Liu Ming, Tang Liqin, Ren Wei, Shi Shaolin

Abstract excerpt

MPV17 is a mitochondrial inner membrane protein, and its deficiency can cause mitochondrial DNA (mtDNA) depletion, increase reactive oxygen species (ROS), and promote apoptosis in several cell types, suggesting that MPV17 plays a protective role in cells although the underlying mechanism remains unknown. To test whether MPV17 is also protective in diabetic kidney disease, we treated Mpv17-deficient mice with...

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Identifiers

PMID: 37522959
DOI: 10.1042/CS20230164
PMCID: PMC10415165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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