Article
IC2 participates in the cooperative activation of outer arm dynein densely attached to microtubules.
Cell structure and function - 23 Sept 2023
Kondo Yusuke, Ogawa Tomoka, Kanno Emiri, Hirono Masafumi, Kato-Minoura Takako, Kamiya Ritsu, Yagi Toshiki
Abstract excerpt
Ciliary outer-arm dynein (OAD) consists of heavy chains (HCs), intermediate chains (ICs), and light chains (LCs), of which HCs are the motor proteins that produce force. Studies using the green alga Chlamydomonas have revealed that ICs and LCs form a complex (IC/LC tower) at the base of the OAD tail and play a crucial role in anchoring OAD to specific sites on the microtubule. In this study, we isolated a novel...
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