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Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat

27 Jul 2018

Abstract excerpt

Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly known. In Chlamydomonas, Dynein-f controls flagellar waveforms but is dispensable for beating. The...

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PMID: 30060180
DOI: 10.1093/jmcb/mjy043

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