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Article

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion

26 Jun 2018

Abstract excerpt

TRIM58 is a member of the tripartite motif protein (TRIM) family of E3 ubiquitin ligases. Aberrant gene methylation of TRIM58 has been reported in liver and lung cancer and indicates a poor patient prognosis. However, the expression level and functional role of TRIM58 in colorectal cancer (CRC) have yet to be elucidated. In the present study, we found that TRIM58 expression was significantly suppressed in human...

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PMID: 29956813
DOI: 10.3892/or.2018.6525

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