Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Genome-Wide Screen for the Exonisation of Reference SINE-VNTR-Alus and Their Expression in CNS Tissues of Individuals with Amyotrophic Lateral Sclerosis

17 Jul 2023

Abstract excerpt

The hominid-specific retrotransposon SINE-VNTR-Alu (SVA) is a composite element that has contributed to the genetic variation between individuals and influenced genomic structure and function. SVAs are involved in modulating gene expression and splicing patterns, altering mRNA levels and sequences, and have been associated with the development of disease. We evaluated the genome-wide effects of SVAs present in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37511314
DOI: 10.3390/ijms241411548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genome-Wide Screen for the Exonisation of Reference SINE-VNTR-Alus and Their Expression in CNS Tissues of Individuals with Amyotrophic Lateral SclerosisPMID 37511314Read ↗

Exploring SVA Insertion Polymorphisms in Shaping Differential Gene Expression in the Central Nervous SystemSemantic proximity Read ↗

Warning SINEs: <i>Alu</i> elements, evolution of the human brain, and the spectrum of neurological diseaseSemantic proximity Read ↗

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosisSemantic proximity Read ↗

Whole genome analyses reveal no pathogenetic single nucleotide or structural differences between monozygotic twins discordant for amyotrophic lateral sclerosis.Semantic proximity Read ↗

The role of non-coding tandem repeat DNA and non-LTR retrotransposons in Amyotrophic Lateral Sclerosis risk lociSemantic proximity Read ↗

Characterisation of the Function of a SINE-VNTR-Alu Retrotransposon to Modulate Isoform Expression at the MAPT LocusSemantic proximity Read ↗

Endogenous retroviruses are dysregulated in ALSSemantic proximity Read ↗

Alu elements: know the SINEs.Semantic proximity Read ↗

Ancient viral DNA in the human genome linked to neurodegenerative diseases.Semantic proximity Read ↗

Characterisation of the Function of a SINE-VNTR-Alu Retrotransposon to Modulate Isoform Expression at the MAPT LocusSemantic proximity Read ↗

Reference SVA insertion polymorphisms are associated with dopaminergic degeneration in Parkinson’s Disease and differential gene expression in the PPMI cohortSemantic proximity Read ↗

A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.