Article
Mutations in Structural Genes of the Mitochondrial Complex IV May Influence Breast Cancer.
Genes - 18 Jul 2023
de Oliveira Ricardo Cunha, Dos Reis Sávio Pinho, Cavalcante Giovanna C
Abstract excerpt
Although it has gained more attention in recent years, the relationship between breast cancer (BC) and mitochondrial oxidative phosphorylation (OXPHOS) is still not well understood. Importantly, Complex IV or Cytochrome C Oxidase (COX) of OXPHOS is one of the key players in mitochondrial balance. An in silico investigation of mutations in structural genes of Complex IV was conducted in BC, comprising 2107...
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