Article
A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm.
Stroke and vascular neurology - 21 Jun 2024
Wen Zhuohua, Feng Xin, Tong Xin, Peng Chao, Xu Anqi, Fan Haiyan, Bi Yiming, Liu Wenchao, Li Zhenjun, Guo Shenquan, Jin Fa, Li Ran, Liu Yanchao, Su Shixing, Zhang Xin, Li Xifeng, He Xuying, Liu Aihua, Duan Chuanzhi
Abstract excerpt
BACKGROUND AND PURPOSE: Recent observational studies have reported that serum total homocysteine (tHcy) is associated with intracranial aneurysms (IAs). However, the causal effect of tHcy on IAs is unknown. We leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA formation. METHODS: We performed a two-sample Mendelian randomisation (MR) using publicly...
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