Article
Frequent MYD88 L265P and CD79B Mutations in Primary Breast Diffuse Large B-Cell Lymphoma.
The American journal of surgical pathology - 1 Mar 2016
Taniguchi Kohei, Takata Katsuyoshi, Chuang Shih-Sung, Miyata-Takata Tomoko, Sato Yasuharu, Satou Akira, Hashimoto Yuko, Tamura Maiko, Nagakita Keina, Ohnishi Nobuhiko, Noujima-Harada Mai, Tabata Tetsuya, Kikuti Yara Yukie, Maeda Yoshinobu, Nakamura Naoya, Tanimoto Mitsune, Yoshino Tadashi
Abstract excerpt
Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare disease comprising <3% of extranodal lymphomas. It frequently reveals an activated B-cell (ABC)-like phenotype. ABC-like DLBCL was reported to have gain-of-function mutations in MYD88, CD79B, CARD11, and TNFAIP3, resulting in constitutive activation of the NFκB pathway. Because of the rare occurrence of PB-DLBCL, the frequency of MYD88 and CD79B...
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