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Article

Investigating the frequency of somatic MYD88 L265P mutation in primary ocular adnexal B cell lymphoma.

Molecular biology reports - 9 Sept 2024

Saraswathi Karuvel Kannan, Santhi Radhakrishnan, Kim Usha, Vanniarajan Ayyasamy

Abstract excerpt

BACKGROUND: Ocular adnexal B cell lymphoma is the most common orbital malignancy in adults. Large chromosomal translocations and alterations in cell-signaling pathways were frequently reported in lymphomas. Among the altered pathways, perturbations of NFκB signaling play a significant role in lymphomagenesis. Specifically, the MYD88 L265P mutation, an activator of NFκB signaling, is extensively studied in...

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PMID: 39249595
DOI: 10.1007/s11033-024-09903-w

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