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Article

Subclones with variants of uncertain clinical significance might contribute to ineffective hemopoiesis and leukemia predisposition.

European journal of haematology - 1 Nov 2023

Giudice Valentina, Serio Bianca, Errichiello Santa, Ferrara Idalucia, Galdiero Alessandra, Bertolini Angela, Visconti Roberta, De Novellis Danilo, Guariglia Roberto, Luponio Serena, Morini Denise, Della Corte Anna Maria, Sessa Anna Maria, Verdesca Francesco, Langella Maddalena, Izzo Barbara, Selleri Carmine

Abstract excerpt

BACKGROUND: Splicing modifications, genomic instability, and hypomethylation are central mechanisms promoting myelodysplasia and acute myeloid leukemia (AML). In this real-life retrospective study, to elucidate pathophysiology of clonal hemopoiesis in hematological malignancies, we investigated clinical significance of mutations in leukemia-related genes of known pathogenetic significance and of variants of...

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Identifiers

PMID: 37501402
DOI: 10.1111/ejh.14069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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