Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes.

doi:10.1016/j.numecd.2023.06.004

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Article

Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Sept 2023

Bódis Kálmán, Bombrich Maria, Schön Martin, Knebel Birgit, Zaharia Oana-Patricia, Bönhof Gidon, Karusheva Yanislava, Strassburger Klaus, Kupriyanova Yuliya, Kotzka Jörg, Guthoff Rainer, Schrauwen-Hinderling Vera, Al-Hasani Hadi, Burkart Volker, Szendroedi Julia, Wagner Robert, Markgraf Daniel F, Roden Michael

Abstract excerpt

BACKGROUND AND AIMS: Increased hepatocellular lipid content (HCL) is linked to insulin resistance, risk of type 2 diabetes and related complications. Conversely, a single-nucleotide polymorphism (TM6SF2EK; rs58542926) in the transmembrane 6 superfamily member 2-gene has been associated with nonalcoholic fatty liver disease (NAFLD), but lower cardiovascular risk. This case-control study tested the role of this...

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Identifiers

PMID: 37495452
DOI: 10.1016/j.numecd.2023.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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