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Article

Lysosome‐dependent FOXA1 ubiquitination contributes to luminal lineage of advanced prostate cancer

26 Jul 2023

Abstract excerpt

Changes in FOXA1 (forkhead box protein A1) protein levels are well associated with prostate cancer (PCa) progression. Unfortunately, direct targeting of FOXA1 in progressive PCa remains challenging due to variations in FOXA1 protein levels, increased FOXA1 mutations at different stages of PCa, and elusive post-translational FOXA1 regulating mechanisms. Here, we show that SKP2 (S-phase kinase-associated protein 2)...

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PMID: 37491794
DOI: 10.1002/1878-0261.13497

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