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Article

Improving the accuracy and internal consistency of regression-based clustering of high-dimensional datasets.

Statistical applications in genetics and molecular biology - 1 Jan 2023

Zhang Bo, He Jianghua, Hu Jinxiang, Chalise Prabhakar, Koestler Devin C

Abstract excerpt

Component-wise Sparse Mixture Regression (CSMR) is a recently proposed regression-based clustering method that shows promise in detecting heterogeneous relationships between molecular markers and a continuous phenotype of interest. However, CSMR can yield inconsistent results when applied to high-dimensional molecular data, which we hypothesize is in part due to inherent limitations associated with the feature...

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PMID: 37489035
DOI: 10.1515/sagmb-2022-0031
PMCID: PMC10891458

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