Article
Stability SCAD: a powerful approach to detect interactions in large-scale genomic study.
BMC bioinformatics - 1 Mar 2014
Gou Jianwei, Zhao Yang, Wei Yongyue, Wu Chen, Zhang Ruyang, Qiu Yongyong, Zeng Ping, Tan Wen, Yu Dianke, Wu Tangchun, Hu Zhibin, Lin Dongxin, Shen Hongbing, Chen Feng
Abstract excerpt
BACKGROUND: Evidence suggests that common complex diseases may be partially due to SNP-SNP interactions, but such detection is yet to be fully established in a high-dimensional small-sample (small-n-large-p) study. A number of penalized regression techniques are gaining popularity within the statistical community, and are now being applied to detect interactions. These techniques tend to be over-fitting, and are...
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