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Article

Nsp3-N interactions are critical for SARS-CoV-2 fitness and virulence.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2023

Li Pengfei, Xue Biyun, Schnicker Nicholas J, Wong Lok-Yin Roy, Meyerholz David K, Perlman Stanley

Abstract excerpt

SARS-CoV-2, the causative agent of COVID-19 encodes at least 16 nonstructural proteins of variably understood function. Nsp3, the largest nonstructural protein contains several domains, including a SARS-unique domain (SUD), which occurs only in Sarbecovirus. The SUD has a role in preferentially enhancing viral translation. During isolation of mouse-adapted SARS-CoV-2, we isolated an attenuated virus that...

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Identifiers

PMID: 37487098
DOI: 10.1073/pnas.2305674120
PMCID: PMC10400999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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