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Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication.

Virology - 1 Jul 2024

Ueno Shiori, Amarbayasgalan Sodbayasgalan, Sugiura Yoshiro, Takahashi Tatsuki, Shimizu Kenta, Nakagawa Keisuke, Kawabata-Iwakawa Reika, Kamitani Wataru

Abstract excerpt

Coronavirus disease 19 is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enveloped virus with a single-stranded positive-sense ribonucleic acid (RNA) genome. The CoV non-structural protein (nsp) 1 is a multifunctional protein that undergoes translation shutoff, messenger RNA (mRNA) cleavage, and RNA binding. The C-terminal region is involved in translational shutoff and RNA cleavage. The...

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Identifiers

PMID: 38593595
DOI: 10.1016/j.virol.2024.110068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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